Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.

Designing RNase H1 “Gapmer” antisense oligonucleotides (ASOs)

This tech note covers ASO mechanisms of action, optimized design guidance, considerations for chemical modifications, in vivo delivery, and more.

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Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.
Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.
Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.
Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.
Click the HTML icon in the toolbar above to edit spacer height.
TO EDIT: Change the class="spacer-3" to any number between 0 (none) and 5 (most) to resize a spacer. Ex. class="spacer-5"
Vertical spacers are responsive and 50% smaller on mobile than on tablet+.
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Design considerations

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Chemical modification guidance

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In vivo delivery targeting