Antisense oligonucleotides (ASOs) are synthetic nucleotides that are designed to modulate gene expression. Learning objectives:
There are different types of ASOs with different mechanisms of action. RNase H1 gapmer ASOs are chemically modified and designed to cleave their target RNAs. Steric blocking ASOs, are often designed to block the splicing machinery to alter splicing outcomes, or to block the ribosome to inhibit translation.
By joining us for our new webinar, you’ll pick up insightful tips on gapmer ASOs, which use the endogenous RNase H1 enzyme to degrade a target RNA.
Antisense oligonucleotides (ASOs) are synthetic nucleotides that are designed to modulate gene expression.
Sr. Staff Scientist Molecular Genetics Research Group, IDT
Kim Lennox is a Senior Staff Scientist in the molecular genetics research group at IDT. Kim is originally from Iowa and obtained a BSc in Genetics at Iowa State University. She then traveled to England to receive her Master’s degree in Biomolecular Archeology at the University of Manchester and University of Sheffield. She started working in the R&D group at IDT over 21 years. For the past two decades, her work has mainly focused on optimizing methods to inhibit the function of different classes of RNAs (mRNAs, miRNAs, lncRNAs, circRNAs, snoRNAs, etc.). She is passionate about assisting and enabling other scientists to develop the best and safest nucleic acid therapeutics to treat genetic diseases.
MS Research Scientist, Molecular Genetics Research Group, IDT
Mollie Schubert is a research scientist in the Molecular Genetics Research Group at IDT. Mollie received her Master's degree in Biochemistry from Iowa State University, and has been with IDT since 2013. For the past five years, Mollie's studies have focused on CRISPR gene editing. Her research has included high-throughput screening of CRISPR-Cas9 guides for the development of a site selection tool, optimization of composition and delivery for synthetic RNA reagents complexed to recombinant CRISPR nucleases, and the development of methods for efficient gene editing, with an emphasis on homology-directed repair.