Alt-R™ CRISPR-Cas9 System

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Genome editing systems can use a wide variety of methods to introduce the molecular components intracellularly. How successful a method is depends on both the delivery protocol and the inherent format of the CRISPR guide RNA(s) and Cas9 enzyme. The Alt‑R™ CRISPR-Cas9 System has been engineered to deliver the optimal performance, and researchers at IDT have shown that the Alt-R CRISPR-Cas9 System provides the highest percentage of on-target genome editing when compared to competing designs, including both native S. pyogenes crRNA:tracrRNA and single, fusion sgRNA triggers. IDT scientists and others are developing methods to effectively deliver the Alt-R ribonucleoprotein (RNP) complex to various cell types and model systems.