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Improve HDR Efficiency in HSPCs Without Compromising Cell Performance

Discover how Kamau Therapeutics improved HDR-mediated correction of the sickle cell mutation in HSPCs while maintaining cell viability and reducing donor template requirements




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The Alt-R™ HDR Enhancer Protein is an invaluable tool for the development of future cell and gene therapy products. It has enabled us to streamline our protocols and increase HDR success rates in HSPCs.

— Matthew Porteus, MD, PhD |Co-Founder and CSO, Kamau Therapeutics

Download the HDR optimization case study