Library preparation and hybridization capture are vital steps in next generation sequencing. Efficient library prep with high sample conversion enables maximal library complexity and deep coverage while hybridization capture selectively enriches regions of interest, enhancing sequencing efficiency, depth, and cost-effectiveness.
While these products can be purchased from different vendors, this requires extra time piece-mealing products together for a comprehensive workflow. Although this method does work, it’s not efficient or sustainable.
By combining the unique splint-ligation strategy of IDT's xGen cfDNA & FFPE DNA Library Prep Kit and xGen Hybridization Capture Panels, a researcher can expect higher on-target rates, coverage, and uniformity with lower duplication rates than when the same products are used with leading competitors with optimal results seen when using the comprehensive xGen workflow.
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Novel splint ligation strategy delivers high conversion of input DNA molecules to NGS library
How xGen library prep compares when it’s used within competitors’ hybridization capture workflows
How using both xGen Lib Prep and Hyb Capture in a comprehensive workflow performs better than competitor