This application note provides an overview of the automated workflow of the xGen cfDNA & FFPE DNA Library Prep v2 MC Kit on the Revvity Sciclone® G3 NGSx workstation. To show the value of this approach, the quality of the automated NGS libraries was measured using key metrics and compared to DNA libraries generated manually. The automated libraries were as high-quality as the manually prepared libraries and generated total yields fit for downstream hybridization capture workflows.